ATE40115T1 - Tetrahydro-benzo (e) isoindoline. - Google Patents
Tetrahydro-benzo (e) isoindoline.Info
- Publication number
- ATE40115T1 ATE40115T1 AT83104932T AT83104932T ATE40115T1 AT E40115 T1 ATE40115 T1 AT E40115T1 AT 83104932 T AT83104932 T AT 83104932T AT 83104932 T AT83104932 T AT 83104932T AT E40115 T1 ATE40115 T1 AT E40115T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- hydrogen
- loweralkyl
- chem
- halo
- Prior art date
Links
- HNCVQRCXEUBSOQ-UHFFFAOYSA-N 2,3,3a,4,5,5a-hexahydro-1h-benzo[e]isoindole Chemical compound C1=CC=CC2CCC3CNCC3=C21 HNCVQRCXEUBSOQ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- -1 benzyloxy, benzoyloxy, thiomethyl Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38363182A | 1982-06-01 | 1982-06-01 | |
| EP83104932A EP0095666B1 (en) | 1982-06-01 | 1983-05-19 | Tetrahydro-benzo(e) isoindolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE40115T1 true ATE40115T1 (de) | 1989-02-15 |
Family
ID=23514004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83104932T ATE40115T1 (de) | 1982-06-01 | 1983-05-19 | Tetrahydro-benzo (e) isoindoline. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0095666B1 (en]) |
| JP (1) | JPS58225064A (en]) |
| KR (1) | KR900001193B1 (en]) |
| AT (1) | ATE40115T1 (en]) |
| AU (1) | AU560459B2 (en]) |
| CA (1) | CA1215376A (en]) |
| DE (1) | DE3378978D1 (en]) |
| ES (1) | ES8503329A1 (en]) |
| NZ (1) | NZ204213A (en]) |
| ZA (1) | ZA833494B (en]) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622405A (en) * | 1984-07-25 | 1986-11-11 | Abbott Laboratories | 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension |
| GR1001059B (el) * | 1988-12-15 | 1993-04-28 | Abbott Lab | Μεθοδος παραγωγης εκλεκτικων παραγοντων 5-ητ. |
| ES2090119T3 (es) * | 1988-12-15 | 1996-10-16 | Abbott Lab | Agentes selectivos de 5-ht. |
| FR2722194B1 (fr) * | 1994-07-06 | 1996-08-23 | Adir | Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent |
| US5792767A (en) * | 1995-01-27 | 1998-08-11 | Abbott Laboratories | Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists |
| ES2168682T3 (es) * | 1996-12-06 | 2002-06-16 | Abbott Lab | Compuestos alfa-1 adrenergicos a base de benzopiranopirrol y de benzopiranopiridina. |
| US5891882A (en) * | 1996-12-06 | 1999-04-06 | Abbott Laboratories | Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3166570A (en) * | 1963-02-15 | 1965-01-19 | American Home Prod | Derivatives of benzo[e] isoindoline and their preparation |
| EP0003757B1 (de) * | 1978-02-08 | 1981-10-14 | Ciba-Geigy Ag | Tricyclische Imidylderivate und Verfahren zu ihrer Herstellung |
| US4282240A (en) * | 1979-11-23 | 1981-08-04 | Merck & Co., Inc. | Amino substituted tetrahydrobenzindoles |
-
1983
- 1983-05-11 AU AU14452/83A patent/AU560459B2/en not_active Ceased
- 1983-05-12 NZ NZ204213A patent/NZ204213A/en unknown
- 1983-05-16 ZA ZA833494A patent/ZA833494B/xx unknown
- 1983-05-19 EP EP83104932A patent/EP0095666B1/en not_active Expired
- 1983-05-19 DE DE8383104932T patent/DE3378978D1/de not_active Expired
- 1983-05-19 AT AT83104932T patent/ATE40115T1/de not_active IP Right Cessation
- 1983-05-30 CA CA000429181A patent/CA1215376A/en not_active Expired
- 1983-05-31 ES ES522875A patent/ES8503329A1/es not_active Expired
- 1983-05-31 KR KR1019830002396A patent/KR900001193B1/ko not_active Expired
- 1983-05-31 JP JP58095088A patent/JPS58225064A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3378978D1 (de) | 1989-02-23 |
| EP0095666A2 (en) | 1983-12-07 |
| KR900001193B1 (ko) | 1990-02-28 |
| JPS58225064A (ja) | 1983-12-27 |
| ZA833494B (en) | 1984-02-29 |
| CA1215376A (en) | 1986-12-16 |
| JPH0443064B2 (en]) | 1992-07-15 |
| EP0095666B1 (en) | 1989-01-18 |
| ES522875A0 (es) | 1985-02-16 |
| AU560459B2 (en) | 1987-04-09 |
| ES8503329A1 (es) | 1985-02-16 |
| KR840005096A (ko) | 1984-11-03 |
| EP0095666A3 (en) | 1985-01-16 |
| AU1445283A (en) | 1983-12-08 |
| NZ204213A (en) | 1986-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |